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云南省瘧疾防治研究所  車立剛  陳文才  楊恒林  黃開國(guó)

全文發(fā)表于《中華流行病學(xué)雜志》1986年第7卷第2期88-91頁(yè)

摘要: 采用WHO推薦的體外微量測(cè)定法和臨床觀察法，調(diào)查云南惡性瘧抗氯喹株地理分布，證實(shí)云南省西南邊境一線，惡性瘧對(duì)氯喹的抗性程度很高，抗性率在96.0％以上，Ⅱ、Ⅲ級(jí)抗性在半數(shù)以上，半數(shù)有效量在6.9微克分子／孔以上；滇中地區(qū)抗性程度低，臨床觀察未發(fā)現(xiàn)抗性病例，體外測(cè)定半數(shù)有效量為2.55微克分子／孔；邊境與滇中地區(qū)之間的地帶，抗性程度居于兩地區(qū)之間。

Investigation report on geographical distribution of chologoquine resistance of falciparum malaria in Yunnan

Che Ligang Chen Wencai Yang Henglin Huang Kaiguo

ABSTRACT.  By means of  Micro-determination in Vitro recommended by  WHO and Clinical obaervation,an investigation of the geographical distribution of drug (Chloroquinine)-resistant strains of  P.falciparum in Yunnan Province was made.It was revealed that in the south-west of Yunnan boarder-line，the resistance of malignant malaria to Chloro quinine therapy was very high，the incidence was higher than 96％，Ⅱ￡Ⅲ degrees being higher than 50%.50% effective dose is over 6.9mgmol／hole；In the Central Area of Yunnan，the degree of drug resistance was low.No drug -resistant clinical case was revealed.50%Effective dose determined in vitro was found to be 2.55ng／hole.The median District between the boarder-line and that of Central Yunnan，the degree of drug Resistance being the median range of the above two levels.