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磷酸咯萘啶與磺胺多辛、伯喹伍用在抗氯喹地區(qū)

時(shí)間:2005-05-10

瀏覽量:3685

 

車立剛  黃開國(guó)  楊恒林      林志良        云南省瘧疾防治研究所

全文發(fā)表于《中國(guó)寄生蟲學(xué)與寄生蟲病雜志》1987年第5卷第3期194-196頁(yè)

 

提要: 將磷酸咯萘啶1.2g與磺胺多辛1.0g、伯喹45mg伍用,在抗氯喹惡性瘧流行區(qū)治療惡性瘧48例,治療后平均退熱時(shí)間32±16h,平均原蟲無性體轉(zhuǎn)陰時(shí)間59±20.8h。服藥后48h瘧原蟲無性體下降率為88~100%,即時(shí)療效與單用磷酸咯萘啶1.2g對(duì)照組相似。伍用組一個(gè)月內(nèi)復(fù)燃率2.5%,服藥后配子體轉(zhuǎn)陰時(shí)間1~12d,并能減少配子體出現(xiàn),根治效果和配子體的作用優(yōu)于單用組。三藥伍用后毒副反應(yīng)無明顯增加,是治療抗氯喹惡性瘧的較好方案。

 

COMBINED USE OF PYRONARIDINE, SULFADOXINE AND PRIMAQUINE IN AREAS WITH CHLOROQUINE-RESISTANT FALCIPARUM MALARIA

Che Ligang, Huang Kaiguo, Yang Henglin, Yu Lei, Lin Zhiliang, Huang Rong

Institute of Malaria Control and Research, Yunnan

 

ABSTRACT.  Fourty-eight falciparum malaria cases were treated by pyronaridine phosphate (1.2gbase)jointly with sulfadimoxine(1g)and primaquine phosphate(45 mg base)in 2 days in Mengla CountyYunnan provincewhere chloroquine-resistant Plasmodium falciparum is endemic.36 falciparum malaria cases were treated with pyronaridine (1.2g)alone.The average defervescence time of the combined treatment group and the pyronaridine grcup was 32±16 h and 32.7±16hthe mean asezual parasite clearance time of the groups was 59±20.8 h and 64±22.9 h respectively.During 1 month follow-upthe asexual parasite recrudescence rate of the 2 groups was 2.5 and 15.2%;the gametocyte-carrying rate was 50.0%(1938and 93.9%(3133.NO marked side effects were observed in the combined therapy.

:轉(zhuǎn)載請(qǐng)注明出處、謝謝合作 

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