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云南省寄生蟲(chóng)病防治所
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青蒿琥酯伍用伯喹治療抗藥性惡性瘧療效觀察

時(shí)間:2005-05-11

瀏覽量:3828

 

車(chē)立剛  李興亮  楊亞明  張有林  李春富  劉慧  張有林

云南省瘧疾防治研究所  思茅  665000

全文發(fā)表于《實(shí)用寄生蟲(chóng)病雜志》1993年第1卷第131-33頁(yè)

 

提要:青蒿琥酯600mg與伯喹90mg伍用,治療抗藥性惡性瘧43例,退熱時(shí)間26.9±19.5h,原蟲(chóng)無(wú)性體轉(zhuǎn)陰時(shí)間33.8±10.4h28d復(fù)燃率6.5%,對(duì)配子體形成和清除有明顯效果,副反應(yīng)少,但療程長(zhǎng),對(duì)G6PD缺陷者不宜。與Fansimef相比,在退熱速度、對(duì)配子體作用、副反應(yīng)方面優(yōu)于后者。

關(guān)鍵詞:抗藥性惡性瘧,青蒿琥酯,復(fù)方甲氟喹

 

EFFICACY OF ARTESUNATE/PRIMAQUINE AGAINST DRUG-RESISTANT FALCIPARUM MALARIA

Che Ligang, Li Xingliang, Yang Yaming, Zhang Youlin

 Li Chunfu, Liu Hui, Shu Wenyi

Institute of Malaria Prevention and Treatment of Yunnan Province, Simao  665000

 

ABSTRACT. Forty-three cases suffered from drug-resistant falciparum malaria were treated with artesunate 600mg and primaquine 90mg.Fever clearance time was 26.9±19.5h, asexual parasite clearance time 33.8±10.4h, and recrudescence rate 6.5% during 28-day´s following-up. The regimen showed good effect on inhibiting gametocytogenesis and clearing gametocytes. It revealed few side-effect but long course of treatment. It is not suitable for treating cases lacking of G-6-PD. Compared with fansimef, it is better on speed of fever clearance, action on gametocytes and side-effect.

Key words: Drug-tesistant, falciparum, malaria, artesunate, mefloquine co

 

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