氯喹加伯喹、復(fù)方乙胺嘧啶加伯喹單劑抑制間日瘧惡性瘧原蟲孢子增殖的效果
時(shí)間：2005-05-10
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云南省瘧疾防治研究所 李華憲 黃國(guó)珍
全文發(fā)表于《中國(guó)寄生蟲防治雜志》1990年第3卷第2期115-117頁
提要：本文觀察了3例思茅的間日瘧病人頓服氯喹（基質(zhì)）600mg＋伯喹（基質(zhì)）22.5mg、2例勐臘的惡性瘧病人頓服乙胺嘧啶70mg＋周效磺胺100mg＋伯喹（基質(zhì)）22.5mg后，藥物在蚊體內(nèi)抑制瘧原蟲孢子增殖的效果。結(jié)果顯示：服藥后8h內(nèi)兩種瘧原蟲在吸血蚊體內(nèi)仍能進(jìn)行孢子增殖；間日瘧原蟲配子體在24～96h內(nèi)轉(zhuǎn)陰，服藥后12h～10d內(nèi)中華按蚊未受感染；惡性瘧原蟲配子體在10d內(nèi)未轉(zhuǎn)陰，服藥后12h～9d內(nèi)大劣按蚊未受感染，其中1例于d10復(fù)燃并使大劣按蚊重獲感染。結(jié)果提示上述服藥方法用于防止傳染源境外輸入時(shí)，對(duì)入境留宿的邊民最好在蚊媒活動(dòng)8h以前給藥。
關(guān)鍵詞：瘧原蟲，配子體，孢子增殖
EFFECT OF COMBINED USE OF CHLOROQUINE/PRIMAQUINE AND PYRIMETHAMINE/SULFAMETHOXINUM/PRIMAQUINE ON THE SPOROGONY OF PLASMODIUM VIVAX AND FALCIPARUM IN ANOPHELES VECTORS
Li Hua-Xian, Huang Guo-Zhen
Yunnan Provincial Antimalaria Institute
ABSTRACT. th vivax malaria was more than 100／u1 and with falciparum malaria，70／ul.
The results showed that the administration of these drugs did noThree patients with vivax malaria from Simao and two patients with falciparum malaria from Mengla were treated orally with acombined dose of chloroquine 600mg／primaquine 22.5mg and pyrimethamine 70mg／sulfamethoxinum 1000mg／primaquine 22.5mg respectively，for observing the effects of the drugs in restraining sporogongy of the parasites in Anopheles veotors. The number of gametocytes in blood from the patients wit restrain the sporogony of P. vivax in An. sinensis and P. falciparum in An. Dirus within 8 hours after treatment. The gametocyte clearance time of P. vivax was 24 or 96 hour，but An. sinensis could not infected 12 hours later or in 10days. The gametocyte of P. falciparum was not cleared as observed for 10days, while it also could cause the An. dirus to be infected.
These results suggest that the time of medication should be 8 hours before contacting with Anopheles vectors when the method is used for preventing the import of the sources of infection.
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