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兩種咯萘啶復(fù)方對(duì)抗氯喹惡性瘧的療效觀察

時(shí)間:2005-05-10

瀏覽量:3686

 

云南省瘧疾防治研究所  車立剛  黃開國(guó)      楊恒林  楊品芳

全文發(fā)表于《中國(guó)寄生蟲病防治雜志》1990年第3卷第124-26頁(yè)

  

提要:磷酸咯萘啶1.2g、磺胺多辛1.5g,伯喹67.5mg伍用;磷酸咯萘啶0.8g與磺胺多辛乙氨嘧啶復(fù)合片伍用,在抗氯喹惡性瘧流行區(qū)分別治療惡性瘧34例和32例,治后平均退熱時(shí)間分別為35.5±19.1h37.3±17.6h,平均瘧原蟲無(wú)性體轉(zhuǎn)陰時(shí)間為58±15.3h59.8±18.9h,一個(gè)月內(nèi)復(fù)燃率為6.5%、13.3%。前者清除配子體時(shí)間為5.4±3.7d,服藥后配子體出現(xiàn)率17.4%,并能阻止惡性瘧原蟲在蚊體內(nèi)的有性繁殖。后者無(wú)此作用。

關(guān)鍵詞:抗氯喹惡性瘧,咯萘啶

EFFICACY OF TWO COMBINED THERAPIES FOR TREATMENT OF CHLOROQUINE-RESISTANT FALCIPARUM MALARIA

Che Ligang, Huang Kaiguo, Dong Ying, Yang Hengli, Yang Pinfang

Yunnan Provincial Institute for Malaria Control

 

ABSTRACT.  Thirty-four cases with falciparum malaria were treated jointly with pyronaridine phosphate(1.2g base)sulfadoxine(1.5g base) and primaquine(67.5mg base) in 3 days in the chloroquine-resistant areas of Mengla and Jinghong CountiesYunnan province. While another group of 32 cases were treated combinedly with pyronaridine phosphate malaridine (0.8g), sulfadoxine(1.0g) and pyrimethamine(50mg) in 2 days. The average defervescent time of the 2 combined therapies were 35.5±19.1h and 37.3±17.6hthe mean asexual parasite clearance time 58±15.3h  and 50.±18.9h respectively.The recrudescence rate of the 2 groups were found to be 6.5 and 13.3after a follow-up of one month. With the former combined therapythe gametocyte-clearance time was 5.4±3.7dthe sexual reproductions of the parasites in Anopheles mosquitos were restrainedwhich was not found when the later therapy was used. No noticeable side effects were observed in both therapies.

 

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