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蒿甲醚治療惡性瘧疾現(xiàn)癥病人83例

時(shí)間:2005-05-10

瀏覽量:3686

 

車立剛  楊恒林  楊品芳  曾家植  強(qiáng) 舒文誼 郭志忠 楊

1  臘縣人民醫(yī)院  666300  2.景洪縣人民醫(yī)院  666150

3.打洛縣打洛鎮(zhèn)衛(wèi)生院  666212

全文發(fā)表于《新藥與臨床》1991年10卷1期47-48頁

 

提要惡性瘧疾現(xiàn)癥病人103例,其中83例(男56例,女27例;年齡25±14yr)用蒿甲醚80mg,im, qd(首劑加倍)5d為一個(gè)療程;兒童用量遞減;其中有腦型惡性瘧1例,并發(fā)黑尿熱者3例;臨床治愈率100%,退熱時(shí)間為37±24h,平均瘧原蟲無性體轉(zhuǎn)陰時(shí)間為47±20h35d內(nèi)的復(fù)燃率達(dá)13%。另外20例用青蒿琥酯60mg,iv, qd(首劑加倍)4d為一個(gè)療程,療效與蒿甲醚相似。

關(guān)鍵詞:惡性瘧原蟲,蒿甲醚/治療應(yīng)用,青蒿琥酯/治療應(yīng)用

 

ARTEMETHER TREATMENT OF FALCIPARUM MALARIA IN 83 PATIENTS

CHE Li-Gang, YANG Heng-Lin, YANG Pin-Fang

Institute of Malaria Control and Research, Simao 665000

AENG Jia-Zhi, ZHANG Qiang,   The People´s Hospital of Mengla, Mengla  666300

SHU Wen-Yi, GUO Zhi-Zhong    The People´s Hospital of Jinghong, Jinghong  666150

YANG Jing    The People´s Hospital of Daluo, Daluo  666212

 

ABSTRACT. Artemether and artesunate are two new antimalarals.In treating 83 patients of acute falciparum malara(M56F27age25±14yr)including one cerebral mala and three complicated with blackwater feverat the dosage of 80mgd im for 5 d(initial loading dose was doubled)the clinical cure rate attained to 100%.The mean defervescence time was 37±24hand the mean parasitenia clearance time was 47±20h.However there was a recurrence rate of 13% within 35d. Another 20 patients were treated with artesunate as control, at the dosage of 60 mg/d, iv, for 4 d (initial loading dose was doubled). Artesunate was similar to artemether in clinincal effect.

Key world: Plasmodium falciparum, artemether/therapeutic use, artesunate / therapeutic use

 

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