時(shí)間:2005-05-10
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車立剛 楊恒林 楊品芳 曾家植 張 強(qiáng) 舒文誼 郭志忠 楊 景
1. 臘縣人民醫(yī)院 666300 2.景洪縣人民醫(yī)院 666150
3.打洛縣打洛鎮(zhèn)衛(wèi)生院 666212
全文發(fā)表于《新藥與臨床》1991年10卷1期47-48頁
提要:惡性瘧疾現(xiàn)癥病人103例,其中83例(男56例,女27例;年齡25±14yr)用蒿甲醚80mg,im, qd(首劑加倍)5d為一個(gè)療程;兒童用量遞減;其中有腦型惡性瘧1例,并發(fā)黑尿熱者3例;臨床治愈率100%,退熱時(shí)間為37±24h,平均瘧原蟲無性體轉(zhuǎn)陰時(shí)間為47±20h,35d內(nèi)的復(fù)燃率達(dá)13%。另外20例用青蒿琥酯60mg,iv, qd(首劑加倍)4d為一個(gè)療程,療效與蒿甲醚相似。
關(guān)鍵詞:惡性瘧原蟲,蒿甲醚/治療應(yīng)用,青蒿琥酯/治療應(yīng)用
ARTEMETHER TREATMENT OF FALCIPARUM MALARIA IN 83 PATIENTS
CHE Li-Gang, YANG Heng-Lin, YANG Pin-Fang
AENG Jia-Zhi, ZHANG Qiang, The People´s Hospital of Mengla, Mengla 666300
SHU Wen-Yi, GUO Zhi-Zhong The People´s Hospital of Jinghong, Jinghong 666150
YANG Jing The People´s Hospital of Daluo, Daluo 666212
ABSTRACT. Artemether and artesunate are two new antimalarals.In treating 83 patients of acute falciparum malara(M56,F27;age25±14yr),including one cerebral mala and three complicated with blackwater fever,at the dosage of 80mg/d im for 5 d(initial loading dose was doubled),the clinical cure rate attained to 100%.The mean defervescence time was 37±24h,and the mean parasitenia clearance time was 47±20h.However there was a recurrence rate of 13% within 35d. Another 20 patients were treated with artesunate as control, at the dosage of 60 mg/d, iv, for 4 d (initial loading dose was doubled). Artesunate was similar to artemether in clinincal effect.
Key world: Plasmodium falciparum, artemether/therapeutic use, artesunate / therapeutic use
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