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楊恒林¹  楊品芳¹  劉德全²  劉瑞君²  董瑩¹  張春勇²  高大慶²  何 慧¹

1．云南省瘧疾防治研究所    云南思茅 665000

2．中國(guó)預(yù)防醫(yī)學(xué)科學(xué)院寄生蟲病研究所    上海  200025

全文發(fā)表于《中國(guó)寄生蟲學(xué)與寄生蟲病雜志》1992年第10卷第3期198-200頁(yè)

 

提要：1988年及1990年在滇南惡性瘧流行區(qū)用體外微量法測(cè)得惡性瘧原蟲對(duì)氯喹、咯萘啶、青蒿琥脂及哌喹的抗性率分別為98.7％（75／76）、  27.6%（16／58）、13.8％（9／65）及97.75（43／44）；半數(shù)抑制量（ID₅₀）分別為125.0、19.0、4.7及243.3nmol／L，抗氯喹惡性瘧原蟲對(duì)哌喹有明顯的交叉抗性；對(duì)咯萘啶及青蒿琥酯則未見明顯的交叉抗性。抗青蒿琥酯惡性瘧原蟲對(duì)以上3種藥均有一定程度的交叉抗性。抗咯萘啶惡性瘧原蟲對(duì)青蒿琥酯無(wú)交叉抗性，而對(duì)氯喹及哌喹有一定程度的交叉抗性。

關(guān)鍵詞：惡性瘧原蟲，體外測(cè)定，氯喹，咯萘啶，青蒿琥酯，哌喹

 

 

SENSITIVITY IN VITRO OF PLASMODIUM FALCIPARUM TO CHLOROQUINE, PYRONARIDINE, ARTESUNATE AND PIPERAQUINE IN SOUTH YUNNAN

Yang Heng-Lin, Yang Pin-Fang, Liu De-Quan, Liu-Rui-Jun

Dong Ying, Zhang Chun-Yong, Gao Da-Qing, He Hui

Institute of Malaria Prevention and Treatment of Yunnan Province, Simao 665000

Institute of Parasistic Diseases, Chinese Academy of Preventive Medicine, Shanghai 200025

 

ABSTRACT. The sensitivity of P.falciparum to chloroquine，pyronaidine，artesunate and piperaquine(CQ，PD，AT，PQ) was assayed using in vitro microtechnique in south Yunnan in 1990. The resistance rates were 98.7％（75／76），27.6（16／58），13.8％（9／65）and 97.7％(43 ／44) repectively, and ID₅₀ were 125.0, 19.0, 4.7 and 243.3nmol/L, respectively. The resistance rate against CQ showed no change as compared to the rates against CQ 5 and 9 years ago；but the ID₅₀ was lower. CQ-resistant P. falciparum showed a marked cross-resistance to Pq, but not to Pd and AT. AT-resistant P. falciparum exhibited cross-resistance to the above- mentioned three drugs. PD-resistant P. falciparum showed no cross redistance to AT, but showed cross resistance to CQ and PQ.

In comparison with chlroquine-coated plates, the plates coated with pyrongaridine, artesunate or piperaquine gave similar results as the former, which were shown by the rise in schizont inhibition rates along with the rise in drug concentration It indicates that pyrona-ridine-, artesunate-, and piperaquine-coated plates can be used in the assay of sensitivity of P. falcipanum to the three drugs.

Key words：Plasmodium falciparum, in vitro microtechnique, chloreoquine, pyronaridine, artesunate, piperaquine.

 

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