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云南省寄生蟲病防治所
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高甲醚片治療瘧疾的療效觀察

時(shí)間:2005-05-11

瀏覽量:3999

 

李興亮1  車立剛1  高白荷1  張有林1  1  李春富1    2  舒文誼3

1.云南省瘧疾防治研究所  思茅  665000     2.勐臘縣醫(yī)院      3.景洪縣醫(yī)院

全文發(fā)表于《實(shí)用寄生蟲病雜志》19942222-24

 

提要:以蒿甲醚口服片劑,總量600mg/d×5在抗氯喹惡性瘧流行區(qū)治療惡性瘧、間日瘧各52例和39例,臨床治愈率均達(dá)100%,退熱時(shí)間、瘧原蟲轉(zhuǎn)陰時(shí)間及近期復(fù)燃率惡性瘧分別為32.6±12.8h31.9 ±12.7  h14.0%,間日瘧分別為27.9±15.2h33.3±10.4h9.7%。結(jié)果顯示,蒿甲醚片劑治療惡性瘧、間日瘧具有與針劑同樣高效、速效及不良反應(yīng)少的優(yōu)點(diǎn)。

關(guān)鍵詞:蒿甲醚片,惡性瘧,間日瘧

 

EFFICACY OF ARTEMETHER TABLET IN TREATMENT OF FALCIPARUM AND VIVAX MALARIA

Li XingLiang1, Che Ligang1, Gao Baihe1,

Zhang Youlin1, Liu Hui1, Li Chunfu1, Zhang Xiang2, Shu Wenyi3

1Institute of Malaria prevention and Treatment of Yunnan Province, Simao  665000

2The people´s Hospital of Mengla County   3The people´s Hospital of Jinghong County

 

ABSTRACT52 cases of falciparun malaria were treated with artemether tablet, a new antimalarial formulation developed in Kunming Pharmaceutical Factory, at the dosage of 100 mg/d×5(initial loading dose was doubled) in chloroquine-resistant region. The clinical cure rate was 100%,the mean defervescence time was 32.6±12.8h and the parasitemia clearance time was 31.9±12.7h. At the same time39 cases of  vivax malaria were treated with same method. The clinical cure rate was 100%,the mean defervescence time 27.9±15.2h and parasitemia clearance time 33.3±10.4h.

The results showed that artemether tablet in the treatment of falciparum and vivax malaria had high efficacy, fasting-acting and less adverse effects as compared with artemether injection, and it may be used for treating chloroquine-resistant falciparum malaria.

Key wordsArtemether tablet, falciparum malaria, vivax malaria

 

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