2020国产在线小视频,2020国产专区视频|2020狠狠操_2020毛片有全集吗？

 

楊恒林  楊品芳  楊亞明     云南省瘧疾防治研究所  思茅  665000

全文發(fā)表于《中國(guó)寄生蟲學(xué)與寄生蟲病雜志》1994年12卷2期140-142頁

 

提要：1992年10－12月在云南南部應(yīng)用體外微量法測(cè)得甲氟喹、奎寧、氨酚喹、氯喹、磺胺多辛／乙胺嘧啶（磺／乙）及咯萘啶對(duì)惡性瘧原蟲的ID₅₀依次為46、480、52、150、2x 10⁴／25×10²及15nmol／L；ID₉₅分別為160、1536、292、680、24×10⁵/3×10⁵及60nmol／L。惡性瘧原蟲對(duì)甲氟喹、奎寧均敏感；對(duì)氨酚喹及氯喹的抗生率分別為100％（30／30）及96.7％（29／30）；咯萘啶測(cè)定5例，其中1例顯示有抗生。20例中有的13例的惡性瘧原蟲可在最高藥量磺／乙井中發(fā)育至裂殖體，提示當(dāng)?shù)貝盒辕懺x對(duì)氯喹與氨酚有明顯交叉抗性，對(duì)奎寧與甲氟喹可能有交叉抗性。

關(guān)鍵詞：惡性瘧原蟲，體外微量法,甲氟喹,奎寧氨酚喹,氯喹，磺胺金辛，乙胺嘧啶，咯萘啶

 

IN VITRO SENSITIVITY OF PLASM ODIUM FALCIPARUM TO MEFLOQUINE, QUININE, AMODIAQUINE, CHLOROQUINE, PYRONARIDINE AND SULFADOXINE / PYRIMETIAMINE IN SOUTH YUNNAN

Yang Henglin, Yang Pinfang, Yang Yaming

Institute of Malaria prevention and Treatment of Yunnan Province, Simao  665000

 

ABSTRACT. The sensitivity of P. falciparum to mifloquine, quinine am odiaquine, chloroquine pyronaridine, and sulfadoxine / pyrimethamine (MEF, QNN, AMO, CHL ,PYR,S/P)was tested using in vitro microtest in south Yunnan Province in 1992. The ID₅₀ were 46, 480, 52, 150, 2x 10⁴／25×10²nmol/L, and 15nmol/L; respectively;ID₉₅ were 160, 1 536, 292, 680, 24×10⁵/3×10⁵nmol/L 60nmol/L, respectively, All the isolates(30) were sensitive to MEF and QMN;100%(30/30) and 96.7%(29/30) isolates were found to be resistant to AMO and CHL, the cross-resis-tance rate was100% to the two drugs. One of 5 isolates exhibited resistance to PYR.The results suggest that the P. falciparum was susceptible to MEF and QNN,but was resistant to AMO,CHLand S/P.CHL-resistant P. faleiparum showed a marked cross-resistance to AMO, but not to MEF,QNN,and S/P; AMO-resistant P. falciparum exhibited cross-res is-tance to CHL, but not to MEF, QNN,and S/P.

Key words: Plasmodium falciparum, in vitro seisitivit, mefloquine, quinine, amodiaquine, chloroquine, sulfadoxine / pyrimethamine

 

注：轉(zhuǎn)載請(qǐng)注明出處、謝謝合作