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李春富¹  張有林¹  李興亮¹  楊亞明¹  劉慧¹  舒文誼²  張翔³  指導者：車立剛

1．云南省瘧疾防治研究所  思茅665000   2．景洪縣醫(yī)院      3．勐臘縣醫(yī)院

全文發(fā)表于《實用寄生蟲病雜志》1994年第2卷第3期31-33頁

 

提要：磷酸咯萘啶800g（基質(zhì)）與復方磺胺多辛2片,伯喹45mg（基質(zhì)）伍用，在抗氯喹惡性瘧流行區(qū)治療惡性瘧42例,平均退熱時間39.0±17.3h；平均原蟲無性體轉(zhuǎn)陰時間41.5±13.6h。服藥后48h瘧原蟲無性體下降率為97.6－100％，28天內(nèi)復燃率為10.3％（3／29）；治后5天內(nèi)配子體清除率達87.5％。與5年前的療效相似。顯示該方案并不隨惡性瘧原蟲對咯萘啶的敏感下降而下降,當?shù)嘏R床觀察證實惡性瘧原蟲對復方磺胺多辛、乙胺嘧啶的抗性率達41.7％。

關鍵詞：磷酸咯萘啶，抗藥性瘧疾，惡性瘧原蟲

 

COMBINATION OF PYRONARIDINE, SULFADOXINE, PYRIMETHAMINE, AND PRIMAQUINE ON FALCIPARUM MALARIA IN MULTI-DRUG RESISTANT AREAS

Li Chunfu¹, Zhang Youlin¹, Li Xingliang¹, Yang Yaming¹

Liu Hui¹, Shu Wenyi², Zhang Xiang³

Instructor： Che Ligang

1. Institute of Malaria prevention and Treatment of Yunnan Province, Simao  665000

2. The people´s Hospital of Jinghong County

3. The people´s Hospital of Mengla County

 

ABSTACT：In 1993,42 malaria cases from southern Yunnan endemic areas with P. falciparum resistant to chloroquine, amodiaquine,piperaquine and sulfadoxine／pyrinethamine were treated with combination of pyronaridine(800mg), sulfadoxine(1000mg), pyrimethamine (50mg) and primaquine (45mg) in 2 days.The results.average defervescent time 39.0±17.3h，mean clearance time of asexual parasite 41.5±13.6h，recrudescence rate 10.3%(3/29) 28 days after treatment, and gametocyte clearance rate 87.5% 5 days after treatment showed no difference as compared with the effect of combintion of pyronaridine (800mg), sulfadoxine(1000mg) and pyrimethamine (50mg) in 1987, though the sensitivity of P. falciparum was decreascd to pyronaridine and sulfadoxine and sulfadoxine / pyrimethamine.

Key words：Pyronaridine, multi-drug resistant,falciparum malaria

 

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