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楊亞明^１  楊恒林^１  董  瑩^１　廖明錚^２

1.云南省瘧疾防治研究所  思茅 665000   2. 云南省瑞麗市防疫站  瑞麗 678000

全文發(fā)表于《實用寄生蟲病雜志》1994年第2卷第3期23-25頁

 

提要：應(yīng)用體外微量法檢測惡性瘧原蟲對氯喹、氨酚喹、青蒿琥酯、還原青蒿琥酯、蒿乙醚及咯萘啶的抗性率，我國境內(nèi)的分別是95.7 %(22/23)、88.9％（8／9）、16.5％(4/24)、22.2％（2／9）、11.1％（1/9）、20.8％（5/24）；半數(shù)抑制量（ID₅₀）分別為176、72、6、13、118、16nmol/L；ID₉₅依次為830、512、34、80、650、88nmol/L。緬甸境內(nèi)的分別為100％（29／29）、83.3％（5／6）、13.8％（4／29）、16.7％（1／6）、21.4％（6／28）；ID₅₀分別為240、52、6、14、120、18nmol／L；ID₉₅為1408、384、34、80、650、96nmol/L。境內(nèi)、外惡性瘧原蟲對奎寧均敏感，ID₅₀分別為608、470nmol/L；ID₉₅為2560，1690nmol/L。證實該地區(qū)惡性瘧原蟲對氯喹普遍存在高度抗性，且緬甸高于我國；對氨酚喹亦普遍產(chǎn)生抗性；對青蒿琥酯，還原青蒿素、蒿乙醚、咯萘啶有少數(shù)瘧原蟲產(chǎn)生低度抗生。抗氯喹惡性瘧原蟲對青蒿琥酯，還原青蒿素、蒿乙醚和咯萘啶無交叉抗性。抗青蒿琥酯惡性瘧原蟲對咯萘啶有交叉抗性。

關(guān)鍵詞：惡性瘧原蟲，抗瘧藥，敏感性，體外測定

 

IN VITRO SENSITIVITY OF PLASMODIUM FALCIPARUM TO SEVEN ANTIMALARIA DRUGS IN CHINA-BURMA BORDER AREA

Yang Yaming，Yang Henglin，Dong Ying

Institute of Malaria Prevention and Treatment of Yunnan Province，Simao   665000

Liao Mingzheng

Sanitary and Anti-epidemic Station of Ruili

ABSTRACT. During 1991-1993, the sensitivity of P. falciparum to chloroquine, amodiaquine, artesunate, dihydroartemisinine, arteether, pyronaridine was detemined with in vitro microtechnique in Ruili border area. The resistance rates in inter-China were 95.7 %(22/23)、88.9％（8／9）、16.5％(4/24)、22.2％（2／9）、11.1％（1/9）、20.8％（5/24）and ID₅₀ were176, 72, 6,13, 118,16 nmol/L; and ID₉₅  were 830、512、34、80、650、88nmol/L respectively. The resistance rates in inter-Burma were in order 100%(29/29), 83.3％（5／6）、13.8％（4／29）、16.7％（1／6）、21.4％（6／28）；ID₅₀  240、52、6、14、120、18nmol／L；ID₉₅  were 1408、384、34、80、650、96nmol/L. Wherever P. falciparum was from Burma or China,it revealed sensitive to quinine. The ID₅₀  were 608 and 470 nmol/L while ID₉₅ 2560 and 1690nmol/L. The results showed that high resistance to chloroquine and amodiaquine had commonly been produced in the area; and resistance in Burma was higher than in China. A few p.falciparum also produced low resistance to artesunate, dihydroartemisinine, arteether, and pyronaridine.

Chloroquine-resistant P. falciparum showed no cross-resistance to artesunate, arteether, dihydroartemisinine, and pyronaridine. But artesunate-resistant p.falciparum exhibited cross-resistance to pyronaridine.

Key words: Plasmodium falciparum, sensitivity, antimalaria drugs, in vitro microtechnique

 

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